Qdenga™▼ Mode of Action

Submitted by Mr Humuun Admin on Mon, 03/28/2022 - 09:39

Qdenga™ is based on a live attenuated DENV-2 virus that provides the genetic backbone for all four virus components in the vaccine1-3
 

See Qdenga™ in action

Developed using recombinant techniques, QdengaTM contains live attenuated dengue viruses1-3

  • QdengaTM is thought to replicate locally and elicit neutralising antibodies to dengue disease caused by any of the four dengue virus serotypes1-5
  • QdengaTM is designed to activate multiple arms of the immune system, including binding antibodies, complement fixing antibodies, functional antibodies to dengue nonstructural protein 1 (NS1) and cell-mediated immune responses (CD4+, CD8+, and natural killer cells)5-10
  • QdengaTM is designed to block a key viral protein (NS1) that contributes to pathogenesis4,8
injection

 

Immune responses elicited by QdengaTM can help protect your patients against dengue disease:2-4

  • Innate immune responses (e.g. interferon)4
  • Adaptive immunity (e.g. neutralising antibodies)2,3,11
  • Cell-mediated and humoral immunity4

▼ This medicinal product is subject to additional monitoring.

GB & NI: Adverse Events should be reported. Reporting forms and information can be found at: www.mhra.gov.uk/yellowcard.

ROI: Adverse Events should be reported to the Pharmacovigilance Unit at the Health Products Regulatory Authority. Reporting forms and information can be found at: www.hpra.ie.

GB, NI and ROI: Adverse Events should also be reported to Takeda UK Ltd at: AE.GBR-IRL@takeda.com

 

References
  1. QdengaTM Summary of Product Characteristics.
  2. Huang CY-H, et al. J Virol. 2003;77(21):11436-11447.
  3. Osorio JE, et al. Vaccine. 2011;29(42):7251-7260.
  4. Chu H, et al. J Infect Dis. 2015;212(1618-1628.
  5. Michlmayr D, et al. J Infect Dis. 2021;223:247-257.
  6. DeMaso CR, et al. J Infect Dis. 2022 Jun 30;jiac272. Doi: 10.1093/infdis/jiac272. Online ahead of print
  7. Tricou V, et al. Vaccine. 2022;40:1143-1151.
  8. Sharma M, et al. J Infect Dis. 2020;221(6):867-877.
  9. Nascimento EJM, et al. Int J Mol Sci. 2021;22:12004.
  10. Waickman AT, et al. Nat Commum. 2019;10(1):3666.
  11. Biswal S, et al. Lancet. 2020;395:1423-1433.

 

 DENV, dengue virus

C-APROM/GB/DENV/0077 | Date of preparation: October 2023

This site has been created by Takeda and is intended for UK and Irish healthcare professionals.
By entering this site, you are confirming that you are a healthcare professional.
This site contains promotional information. 

I am a healthcare professional

I am a member of the public I am a patient

C-ANPROM/GB/QDE/0007 | Date of preparation October 2023